Articles

Effects of Laser Therapy on Experimental Wound Healing Using Oxidized Regenerated Cellulose Hemostat

Soares, L.P., DeOliveira, M.G., Pinheiro, A.L.B., Fronza, B.R., Maciel, M.E.S.
Photomedicine and Laser Surgery 2008
26(1): 10-13

Objective: The aim of this paper was to evaluate if the healing of wound sites containing oxidized regenerated cellulose hemostat can be optimized by laser therapy.

Background Data: Topical hemostatic agents may be used to control bleeding in a variety of surgical sites. Hemostatic oxidized regenerated cellulose can cause strange body reactions and formation of granulomas.

Material and Methods: Thirty-six male Wistar rats averaging 6 wk of age, weighting 250 g each, were anesthetized had a standard 0.5-cm² block of oxidized regenerated cellulose (Surgicel™) inserted into an incision on the back of the tongue. Postoperatively the animals were randomly divided into two groups of 18 animals each: one was irradiated and one was not irradiated (control). In the treatment group, transmucosal laser therapy was applied in one area (Ga-Al-As laser, 4 J/cm², λ = 685 nm, 35 mW, θ = 0.06 mm) and consisted of four sessions, with one session carried out every 48 h. The animals were killed at three different times: G1 (1d), G2 (3d), and G3 (7d). Tissues were stained with hematoxylin and eosin and then analyzed.

Results: It was observed that the treated group exhibited a greater reduction in edema and inflammatory infiltrate.

Conclusions: These results suggest that laser therapy at 685 nm could improve the healing process, even when the inflammatory process has been stimulated by oxidized regenerated cellulose hemostat.

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